Currently, reports indicate CBD is considered safe to use. However, most agree that much more research is still needed to determine if there are any major side effects. This is why clinical trials are necessary to conduct before it is legalized as a medicine worldwide.
Research has been done on some levels, in 2015, GW Pharmaceuticals released interim results of its clinical trials. The report showed that “The safety profile of CBD was particularly reassuring, with no serious adverse events and an overall frequency of adverse events very similar to placebo. They further stated the most common adverse events (occurring in 5% or more patients resulting from all causes) were Diarrhea, Nausea, and Headache.”
Is CBD Considered Safe?
A review of the scientific literature by Bergamaschi (2011), published in “Current Drug Safety,” showed that CBD is non-toxic, does not affect physiological parameters (heart rate, blood pressure, and body temperature), does not affect gastrointestinal transit, and does not alter psychomotor or psychological functions.
High doses up to 1,500 mg/day of CBD are reportedly tolerated well in humans. Small-scale studies have found that people generally tolerate CBD well, but some individuals may experience mild side effects. These include:
tiredness and trouble sleeping
Clinical trials of Epidiolex, the brand name of the CBD medication that the United States Food and Drug Administration (FDA) have approved to treat epilepsy, did not find any indications of physical dependence.
Cannabinoids, such as CBD, attach themselves to specialized receptors in a person’s brain and immune system. One of these receptors, called a CB2 receptor, plays a role in the immune system by managing pain and inflammation.
Researchers believe that when CBD enters a person’s body, it may attach to CB2 receptors. Alternatively, it may cause the body to produce natural cannabinoids that attach to the CB2 receptors.
Either way, scientists think CBD affects the way that these receptors respond to the signals that they receive, possibly helping reduce inflammation and pain.
A 2008 review of research into CBD and its possible mechanism of action suggested that CBD could play a role in chronic pain management.